The coming of age of gene therapy: A review of the past and path forward
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A new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell. If the treatment is successful, the new gene will make a functional protein.
After three decades of hopes tempered by setbacks, gene therapy -- the process of treating a disease by modifying a person's DNA -- is no longer the future of medicine, but is part of the present-day clinical treatment toolkit. The Jan. 12 issue of the journal Scienceprovides an in-depth and timely review of the key developments that have led to several successful gene therapy treatments for patients with serious medical conditions...More